MISTIE Clinical Trial

Intracerebral Brain Hemorrhage
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Prelude EDC
MINIMALLY INVASIVE SURGERY plus T-PA for

   INTRACEREBRAL HEMORRHAGE EVACUATION
 

Intracerebral Hemorrhage (ICH) is the only major stroke subtype (ischemic, aneurysm rupture, and parenchymal hemorrhage) without a clearly effective treatment. ICH occurs in over 100,000 Americans yearly. African Americans, Hispanics and Asians are disproportionately affected. ICH is fatal in 30 to 50% of all occurrences. It leaves the majority of the survivors with significant motor and cognitive disability.
 
Compared to ischemic stroke, ICH is easily and rapidly identified, occurs in younger patients, and produces a smaller initial injury to cerebral tissues—all factors suggesting that interventional amelioration is possible. The investigations of the last decade have established that the extent of ICH-mediated brain injury relates directly to the volume of blood clot and duration of blood exposure to the brain tissue. We propose to produce data regarding the capability of minimally invasive surgery (MIS) with recombinant tissue plasminogen activator (rt-PA) to remove blood clot from ICH patients.
 
The MISTIE study was designed to unearth previously unavailable data about ICH dissolution and different doses of rt-PA, a safety estimate for MIS + rt-PA, in-situ pharmacokinetic behavior and dose-response properties, surgical data regarding the validity and safety of patient selection, quantitation of surgical effectiveness, and objective definitions of patient stability and disease/treatment-related complications. These previously unavailable data are critical to precisely defining a treatment for this last, untreated stroke type: ICH. This proposed study would provide the first test of the relation between clot removal and outcome for brain hemorrhage.
 
Click Here for information on the ICES (Endoscopy) arm of the MISTIE-ICES trial.
 

Please click here to read more about Johns Hopkins' Notice of Privacy Practices. 

 Surgeons' Meetings                         

 

Dr. Mario Zuccarello will host a review of the minimally invasive ICH evacuation technique, and share findings of a recent catheter placement review. 

Click here to register. 

 

 

 

Monthly Teleconferences               

 

Click here register for the recurring monthly teleconference.

 

 Pharmacy Training Sessions         

 

The study's head pharmacist, Janet Mighty, will be hosting training sessions to review drug preparation.  Click here to register for one of the upcoming Pharmacy Training sessions. 

 

 

 

 MISTIE Featured on WYPR          

 

Dr. Judy Huang, the PI surgeon at Johns Hopkins University, gives a brief description of the MISTIE procedure, as might be appropriate in an initial family consent.  Click here to listen.